Volume 15, Issue 3 (Journal of Control, V.15, N.3 Fall 2021)                   JoC 2021, 15(3): 13-22 | Back to browse issues page

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Sohrabi N, Alihosseini A, Piroozfar V, Zamani Pedram M. Design of the optimal magnetic field in application of functionalized CNT-based drug delivery toward the cell membrane: Computational Analysis. JoC 2021; 15 (3) :13-22
URL: http://joc.kntu.ac.ir/article-1-762-en.html
Design of the optimal magnetic field in application of functionalized CNT-based drug delivery toward the cell membrane: Computational Analysis
Nafiseh Sohrabi1 , Afshar Alihosseini1 , Vahid Piroozfar1 , Maysam Zamani Pedram * 2
1- Central Tehran Branch, Islamic Azad University
2- KN Toosi University of Technology
Abstract:   (12951 Views)
Recently, Carbon Nano (CN) structures are widely used in medical applications, especially the detection and treatment of cancer disease. Among various types of CNs, Carbone Nano Tubes (CNTs) attracted many researchers' attention to consider them toward clinical application. Regarding the intrinsic structure of CNTs, they can be used widely in drug delivery applications. Functionalized CNTs and conjugated with drug and magnetic nanoparticles (MNPs), represents an opportunity toward targeted drug delivery. In the mentioned system, MNPs play as a magnetic actuator, which can be externally excited. Delivery of the drug to a specific area, specifically inside the cellular membrane, is essential. To conduct a well-designed delivery system, the interaction force profile is needed to cross the CNTs through the membrane. The process is the primary point in a targeted drug delivery system. In this study, the computational analysis of crossing functionalized /CNTs containing anti-cancer drug through the cell membrane (lung cell) are investigated. The mathematical model shows the frequency behaviour of the cell membrane and provides a physical relation between crossing velocities and interaction forces.  In this paper, the result is based on a complex Molecular scale simulation in which they entirely compute the producer of drug delivery. The dynamics equation of the system is presented in the time and frequency domain, which can lean to provide an optimal external magnetic field profile. This design helps nanotechnologist to precisely analyze drug delivery dynamics during the time and how to implement in clinical applications. The results provide an optimal profile to deliver the drug and crossing through the cell membrane in 30 seconds, 1, 2 and 5 minutes.
Keywords: Carbon Nano Tube (CNT), Molecular Scale Modeling, MD simulation, System Identification, Magnetic field, Optimized design
Full-Text [PDF 747 kb]   (1376 Downloads)    
Type of Article: Research paper | Subject: Special
Received: 2020/05/19 | Accepted: 2021/02/15 | ePublished ahead of print: 2021/02/26 | Published: 2022/02/1
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